Mewtwo ( ; Japanese: ミュウツー, Hepburn: Myūtsū) is a Pokémon species in Nintendo and Game Freak's Pokémon media franchise. It was first introduced in the video games Pokémon Red and Blue, and later appeared in subsequent sequels and spin-off titles, such as Pokkén Tournament and Detective Pikachu. In the video games, the player can fight and capture Mewtwo in order to subsequently pit it against other Pokémon. The player can first learn of Mewtwo late in Pokémon Red and Blue by reading research documents left in a ruined laboratory on Cinnabar Island where Mewtwo has escaped. Mewtwo is regarded as one of the series' strongest Pokémon, and was the strongest in the original games in terms of base statistic distribution. It is known as the "Genetic Pokémon" and is a Legendary Pokémon, a special group of Pokémon that are very rare and usually very powerful. Mewtwo has also appeared in various animated adaptations of the franchise.
Masachika Ichimura was the first to voice the original Mewtwo character in Japanese, and the creature's younger self is voiced by Fujiko Takimoto in the Sound Picture Box: Mewtwo's Origin CD drama and Showtaro Morikubo in the anime adaptation. In English, Jay Goede voiced Mewtwo in Pokémon: The First Movie (being credited under the pseudonym "Philip Bartlett") and the Pokémon Live! musical, while Dan Green provided the voice for The First Movie's direct sequel, Pokémon: Mewtwo Returns. Green reprised the role in the 2019 remake of the first Pokémon movie, Pokémon: Mewtwo Strikes Back Evolution.
Actress Reiko Takashima voiced a second, unrelated Mewtwo in the Pokémon anime special Mewtwo: Prologue to Awakening and its direct sequel, Pokémon the Movie: Genesect and the Legend Awakened; this second Mewtwo is voiced by actress Miriam Pultro in the English dub. Mewtwo has featured in other game franchises, such as Super Smash Bros. series, in which Ichimura reprised in Super Smash Bros. Melee and Keiji Fujiwara in Super Smash Bros. for Nintendo 3DS and Wii U and Super Smash Bros. Ultimate. A third Mewtwo also appears in the 2019 live-action animated film Detective Pikachu, voiced simultaneously by Rina Hoshino and Kotaro Watanabe.
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